Posts

Breast Cancer Treatment: A Review

Breast Cancer Treatment: A Review. (2019). Waks A, Wilner E. JAMA. Overview: - breast cancer will be diagnosed in 12% of women in the US over their lifetimes - 3 major subtypes based on molecular markers (ER, PR, and HER2). - more than 90% of breast cancers not metastatic at time of diagnosis - if no mets, tx goals is tumor eradication and prevent recurrence - local therapy for nonmetastatic cancer = surgical resection. mastectomy vs lumpectomy + radiation - median OS for metastatic triple negative is ~1 yr, vs 5 yrs for other subtypes Her2 = human epidermal growth factor 2, renamed as ERBB2. ---- Prevelance/Prognosis/Tx For 3 Breast Cancer Subtypes Overview 1. HR+ / ERBB2- - >1% of tumors stain + or ER or PR proteins. Estrogen receptor A activates oncogenic growth patterns - 70% of breast cancers. >99% are stage 1 with 5 y breast cancer specific survival - metastatic median OS = 4-5 yrs Treatment: - endocrine therapy (all patients) = tamoxifen, letrozole, ana...
Post a Comment
Read more

Breast Cancer Staging

Anatomy and Breast Cancer Staging. (2018). Plichta, J et al. Take Aways: - anatomic staging for breast cancer gives prognostic information - prognostic staging for breast cancer includes both anatomic factors and tumor-specific factors (receptor status and genomic profiles) - including tumor biology into new staging system will improve further discrimination of prognosis between tumor stages ---- Traditional Staging System - UICC (international union against cancer) created the TNM system > T: Tumor > N: Nodes > M: Metastasis - adopted by the AJCC Cancer Staging Manual Now there are 2 staging systems: the anatomic stage and prognostic stage 1. Anatomic stage - TNM from clinical and/or pathological assessments 2. Prognostic Stage - tumor grade - receptor status (ER, PR, HER2 status) - tumor multigene panel testing (oncotype Dx, Genomic Health, etc) NCCN guidelines for invasive breast cancer staging workup needs: - H&P - diagnostic b/l mammogram ...
Post a Comment
Read more